Even though recent genetic studies identified over 50 genetic locations, dietary interventions and proper lifestyle changes can prevent obesity development in genetically predisposed people.
Therefore, screening programs could be useful in identifying high-risk children, who could benefit from proper prophylactic measures. Perhaps, further studies should also focus on developing targeted genetic interventions designed for children that carry the burden of obesity risk.
Nutrigenomics intervention directing macronutrient breakdown, encouraging substitution of healthy foods with appropriate caloric intake, encouraging physical activity and behavioral modifications could begin easily at home.
Obesity during childhood can have a harmful effect on the body in a variety of ways. Children who have obesity are more likely to have:
- High blood pressure and high cholesterol, which are risk factors for cardiovascular disease (CVD).
- Increased risk of impaired glucose tolerance, insulin resistance, and type 2 diabetes.
- Breathing problems, such as asthma and sleep apnea.
- Joint problems and musculoskeletal discomfort.
- Fatty liver disease, gallstones, and gastro-esophageal reflux (i.e., heartburn).
Childhood obesity is also related to:
- Psychological problems such as anxiety and depression.
- Low self-esteem and lower self-reported quality of life.
- Social problems such as bullying and stigma.
Childhood obesity begins at home and so do the above complications that arise from not addressing the problem early before it migrates into adulthood.
You’ve probably heard good stuff about omega-3 fatty acids. Why are Omega-3 fatty acids all the rage? Healthy sources of dietary fat are a huge part of a wellness diet. Fats are used to:
- Stimulate proper cell health (all of our cells membranes are made of fatty acids)
- Help absorb certain vitamins (like A, D, E, and K)
- Promote healthy skin and joints
- Support brain and cardiovascular health (our brains are made up of 60% fat!)
Omega-3 is one of our “essential” fatty acids, which means that our body doesn’t manufacture it on its own so we have to take it in through our diet.There is accumulating evidence that genetic predisposition in genes like CD36, NOS3 and PPARG may also affect the need for fish oil supplements.
Omega 3s in particular have been associated with several specific health benefits, like helping to reduce inflammation, supporting the cardiovascular system, and promoting overall brain and neurological function.
There are a differences in omega-3s. Which ones do we need to know about?
There are 4 forms of omega-3s found in different food sources:
- EPA (eicosapentaenoic acid, C20:5, n-3*)
- DHA (docosahexaenoic acid, C22:6, n-3)
- DPA (docosapentaenoic acid , C22:5, n-3)
- ALA (alpha-linolenic acid, C18:3, n-3) – plants
…and forms of omega-6s found in many processed food sources.
- ARA (arachidonic acid
- LA (linoleic acid
Where can we find them exactly?
EPA, DHA and DPA are found mostly in wild, cold-water fish like salmon, sardines, shrimp, flounder, and trout (among others). These types of omega-3s have been associated with many of the brain and cardiovascular benefits related to healthy fats. These types are high in fish because they come from algae—that’s why algae oil supplements have become a popular plant-based alternative to fish and fish oils.
DHA is the most abundant omega-3 fat in the brain, making up 90% of the total omega content of the brain and 15-20% of the brain’s total lipid content.
The forth form of omega-3 is ALA, which is found in plant-based omega-3 sources like chia seeds, walnuts, hemp seeds, flaxseed, canola, and many other nuts and seeds. ALA can be converted to EPA and DHA in the body, but it requires larger amounts to do so.
Omega 3 v. Omega 6: What’s the diff?
Omega-3s are known to be more anti-inflammatory, while omega-6s are known to be pro-inflammatory. Omega-6 is found in vegetable oils and ultra-processed food, and since processed food currently makes up over 60% of the standard American diet, many people are taking in too much.
An aspect of fatty acids metabolism that gets a lot of attention is the ratio of omega-6 to omega-3. The standard American diet tends to be very rich in sources of omega-6 fats and deficient in adequate sources of omega-3 — this ratio has been reported to be as high as 10:1 to 20:1, while recommendations promote a balance closer to 4:1 or 2:1. The body will maintain the ratio as long as sufficient omega-3 is provided in the diet or as supplements.
“I’m going to make you work hard,” a blonde and perfectly muscled fitness instructor screamed at me in a recent spinning class, “so you can have that second drink at happy hour!”
At the end of the 45-minute workout, my body was dripping with sweat. I felt like I had worked really, really hard. And according to my bike, I had burned more than 700 calories. Surely I had earned an extra margarita.
The spinning instructor was echoing a message we’ve been getting for years: As long as you get on that bike or treadmill, you can keep indulging — and still lose weight. It’s been reinforced by fitness gurus, celebrities, food and beverage companies like PepsiCo and Coca-Cola, and even public-health officials, doctors, and the first lady of the United States. Countless gym memberships, fitness tracking devices, sports drinks, and workout videos have been sold on this promise.
There’s just one problem: This message is not only wrong, it’s leading us astray in our fight against obesity.
To find out why, I read through more than 60 studies on exercise and weight loss. I also spoke to nine leading exercise, nutrition, and obesity researchers. Here’s what I learned.
1) An evolutionary clue to how our bodies burn calories
When anthropologist Herman Pontzer set off from Hunter College in New York to Tanzania to study one of the few remaining hunter-gatherer tribes on the planet, he expected to find a group of calorie burning machines.
Unlike Westerners, who increasingly spend their waking hours glued to chairs, the Hadza are on the move most of the time. Men typically go off and hunt — chasing and killing animals, climbing trees in search of wild honey. Women forage for plants, dig up tubers, and comb bushes for berries. “They’re on the high end of physical activity for any population that’s been looked at ever,” Pontzer said.
By studying the Hadza’s lifestyle, Pontzer thought he would find evidence to back the conventional wisdom about why obesity has become such a big problem worldwide. Many have argued that one of the reasons we’ve collectively put on so much weight over the past 50 years is that we’re much less active than our ancestors.
Surely, Ponzer thought, the Hadza would be burning lots more calories on average than today’s typical Westerner; surely they’d show how sluggish our bodies have become.
On several trips in 2009 and 2010, he and his colleagues headed into the middle of the savanna, packing up a Land Rover with camping supplies, computers, solar panels, liquid nitrogen to freeze urine samples, and respirometry units to measure respiration.
In the dry, open terrain, they found study subjects among several Hadza families. For 11 days, they tracked the movements and energy burn of 13 men and 17 women ages 18 to 75, using a technique called doubly-labeled water — the best known way to measure the carbon dioxide we expel as we burn energy.
When they crunched the numbers, the results were astonishing.
“We were really surprised when the energy expenditure among the Hadza was no higher than it is for people in the US and Europe,” says Pontzer, who published the findings in 2012 in the journal PLoS One. While the hunter-gatherers were physically active and lean, they actually burned the same amount of calories every day as the average American or European, even after the researchers controlled for body size.
Pontzer’s study was preliminary and imperfect. It involved only 30 participants from one small community.
But it raised a tantalizing question: How could the hunting, foraging Hadza possibly burn the same amount of energy as indolent Westerners?
As Pontzer pondered his findings, he began to piece together an explanation.
First, scientists have shown that energy expenditure — or calories burned every day — includes not only movement, but all the energy needed to run the thousands of functions that keep us alive. (Researchers have long known this, but few had considered its significance in the context of the global obesity epidemic.)
Calorie burn also seems to be a trait humans have evolved over time that has little to do with lifestyle. Maybe, Pontzer thought, the Hadza were using the same amount of energy as Westerners because their bodies were conserving energy on other tasks.
Or maybe the Hadza were resting more when they weren’t hunter-gathering to make up for all their physical labor, which would also lower their overall energy expenditure.
This science is still evolving. But it has profound implications for how we think about how deeply hardwired energy expenditure is and the extent to which we can hack it with more exercise.
If the “calories out” variable can’t be controlled very well, what might account then for the difference in the Hadza’s weights?
“The Hadza are burning the same energy, but they’re not as obese [as Westerners],” Pontzer said. “They don’t overeat so they don’t become obese.”
This fundamental concept is part of a growing body of evidence that helps explain a phenomenon researchers have been documenting for years: that it’s extremely difficult for people to lose weight once they’ve gained it by simply exercising more.
2) Exercise is excellent for health
Before we dive into why exercise isn’t that helpful for slimming, let’s make one thing clear: No matter how working out impacts your waistline, it does your body and mind good.
A Cochrane Review of the best-available research found that, while exercise led to only modest weight loss, study participants who exercised more (even without changing their diets) saw a range of health benefits, including reducing their blood pressure and triglycerides in their blood. Exercise reduces the risk of Type 2 diabetes, stroke, and heart attack.
A number of other studies have also shown that people who exercise are at a lower risk of developing cognitive impairment from Alzheimer’s and dementia. They also score higher on cognitive ability tests — among many, many other benefits.
If you’ve lost weight, exercise can also help weight maintenancewhen it’s used along with watching calorie intake. Exercise, in summary, is like a wonder drug for many, many health outcomes.
3) Exercise alone is almost useless for weight loss
The benefits of exercise are real. And stories about people who have lost a tremendous amount of weight by hitting the treadmill abound. But the bulk of the evidence tells a less impressive story.
Consider this review of exercise intervention studies, published in 2001: It found that after 20 weeks, weight loss was less than expected, and that “the amount of exercise energy expenditure had no correlation with weight loss in these longer studies.”
To explore the effects of more exercise on weight, researchers have followed everybody from people training for marathons to sedentary young twins, and post-menopausal overweight and obese women who ramp up their physical activity through running, cycling, or personal training sessions. Most people in these studies typically only lost a few pounds at best, even under highly controlled scenarios where their diets were kept constant.
Other meta-analyses, which looked at a bunch of exercise studies, have come to similarly lackluster conclusions about exercise for losing weight. This Cochrane Review of all the best-available evidence on exercise for weight loss found that physical activity alone led to only modest reductions. Ditto for another review published in 1999.
University of Alabama obesity researcher David Allison sums up the research this way: Adding physical activity has a very modest effect on weight loss — “a lesser effect than you’d mathematically predict,” he said.
We’ve long thought of weight loss in simple “calories in, calories out” terms. In a much-cited 1958 study, researcher Max Wishnofsky outlined a rule that many organizations — from the Mayo Clinic to Livestrong — still use to predict weight loss: A pound of human fat represents about 3,500 calories; therefore cutting 500 calories per day, through diet or physical activity, results in about a pound of weight loss per week. Similarly, adding 500 calories a day results in a weight gain of about the same.
Today, researchers view this rule as overly simplistic. They now think of human energy balance as “a dynamic and adaptable system,” as one study describes. When you alter one component — cutting the number of calories you eat in a day to lose weight, doing more exercise than usual — this sets off a cascade of changes in the body that affect how many calories you use up, and in turn, your body weight.
4) Exercise accounts for a small portion of daily calorie burn
One very underappreciated fact about exercise is that, even when you work out, those extra calories burned only account for a tiny part of your total energy expenditure.
“In reality,” said Alexxai Kravitz, a neuroscientist and obesity researcher at the National Institutes of Health, “it’s only around 10 to 30 percent [of total energy expenditure] depending on the person (and excluding professional athletes that workout as a job).”
There are three main components to energy expenditure, Kravitz explained: 1) basal metabolic rate, or the energy used for basic functioning when the body is at rest; 2) the energy used to break down food; and 3) the energy used in physical activity.
We have very little control over our basal metabolic rate, but it’s our biggest energy hog. “It’s generally accepted that for most people, the basal metabolic rate accounts for 60 to 80 percent of total energy expenditure,” Kravitz said. Digesting food accounts for about 10 percent.
“It’s not nothing, but it’s not nearly equal to food intake — which accounts for 100 percent of the energy intake of the body,” Kravitz said. “This is why it’s not so surprising that exercise leads to [statistically] significant, but small, changes in weight.”
5) It’s hard to create a significant calorie deficit through exercise
Using the National Institutes of Health Body Weight Planner — which gives a more realistic estimation for weight loss than the old 3,500 calorie rule — mathematician and obesity researcher Kevin Hall created this model to show why adding a regular exercise program is unlikely to lead to significant weight loss.
If a hypothetical 200-pound man added 60 minutes of medium intensity running four days per week while keeping his calorie intake the same, and he did this for 30 days, he’d lose five pounds. “If this person decided to increase food intake or relax more to recover from the added exercise, then even less weight would be lost,” Hall added. (More on these “compensatory mechanisms” later.)
So if one is overweight or obese, and presumably trying to lose dozens of pounds, it would take an incredible amount of time, will, and effort to make a real impact through exercise.
6) Exercise can undermine weight loss in other, subtle ways
How much we move is connected to how much we eat. As Hall put it, “I don’t think anybody believes calories in and calories out are independent of each other.” And exercise, of course, has a way of making us hungry — so hungry that we might consume more calories than we just burned off.
One 2009 study shows that people seemed to increase their food intake after exercise — either because they thought they burned off a lot of calories or because they were hungrier. Another review of studies from 2012 found people generally overestimated how much energy exercise burned and ate more when they worked out.
“You work hard on that machine for an hour, and that work can be erased with five minutes of eating afterward,” Hall added. A single slice of pizza, for example, could undo the calories burned in an hour’s workout. So could a cafe mocha or an ice cream cone.
There’s also evidence to suggest that some people simply slow down after a workout, using less energy on their non-gym activities. They might decide to lay down for a rest, fidget less because they’re tired, or take the elevator instead of the stairs.
These changes are usually called “compensatory behaviors” — and they simply refer to adjustments we may unconsciously make after working out to offset the calories burned.
7) Exercise may cause physiological changes that help us conserve energy
The most intriguing theories about why exercise isn’t great for weight loss describe changes in how our bodies regulate energy after exercise.
Researchers have discovered a phenomenon called “metabolic compensation.”
“The more you stress your body, we think there are changes physiologically — compensatory mechanisms that change given the level of exercise you’re pushing yourself at,” said Loyola University exercise physiologist Lara Dugas. In other words, our bodies may actively fight our efforts to lose weight.
This effect has been well documented, though it may not be the same for everyone.
For one fascinating study, published in the journal Obesity Research in 1994, researchers subjected seven pairs of sedentary young identical twins to a 93-day period of intense exercise. For two hours a day, nearly every day, they’d hit a stationary bike.
The twins were also housed as in-patients in a research lab under 24-hour supervision and fed by watchful nutritionists who measured their every calorie to make sure their energy intake remained constant.
Despite going from being mostly sedentary to spending a couple of hours exercising almost every day, the participants only lost about 11 pounds on average, ranging from as little as 2 pounds to just over 17 pounds, almost all due to fat loss. The participants also burned 22 percent fewer calories through exercise than the researchers calculated prior to the study starting.
By way of explanation, the researchers wrote that either subjects’ basal metabolic rates slowed down or they were expending less energy outside of their two-hour daily exercise block.
Dugas called this phenomenon “part of a survival mechanism”: The body could be conserving energy to try to hang on to stored fat for future energy needs. Again, researchers don’t yet know why this happens, and how long the effects persist in people.
“We know with confidence that some metabolic adaptions occur under some circumstances,” said David Allison, “and we know with confidence some behavioral compensations occur under some circumstances. We don’t know how much compensation occurs, under which circumstances, and for whom.”
8) Energy expenditure might have an upper limit
Another hypothesis about why it’s hard to lose weight through exercise alone is that energy expenditure plateaus at a certain point. In another Pontzer paper, published in 2016 in the journal Current Biology, he and his colleagues found evidence of an upper limit.
They cast a wide geographic net, recruiting 332 adults from Ghana, South Africa, Seychelles, Jamaica, and the United States. Tracking the study participants for eight days, they gathered data on physical activity and energy burned using accelerometers. They classified people into three types: the sedentary folks, the moderately active (who exercised two or three times per week), and the super active (who exercised about every day). Importantly, these were people who were already doing a certain amount of activity, not people who were randomized to working out at various levels.
Here, physical activity accounted for only 7 to 9 percent of the variation in calories burned among the groups. Moderately active people burned more energy than people who were sedentary (about 200 calories more each day), but above that, the energy used up seemed to hit a wall.
“After adjusting for body size and composition,” the researchers concluded in the study, “total energy expenditure was positively correlated with physical activity, but the relationship was markedly stronger over the lower range of physical activity.”
In other words, after a certain amount of exercise, you don’t keep burning calories at the same rate: Total energy expenditure may eventually plateau.
“That plateau is really different than the standard way of thinking about energy expenditure,” Pontzer said. “What the World Health Organization and the people who build the Fitbit would tell you is that the more active you are, the more calories you burn per day. Period, full stop.”
Based on the research, Pontzer has proposed a new model that upends the the old “calories in, calories out” approach to exercise, where the body burns more calories with more physical activity in a linear relationship (also known as the “additive” model of energy expenditure).
He calls this the “constrained model” of energy expenditure, which shows that the effect of more physical activity on the human body is not linear. In light of our evolutionary history — when food sources were less reliable — he argues that the body sets a limit on how much energy it is willing to expend, regardless of how active we are.
“The overarching idea,” Pontzer explained, “is that the body is trying to defend a particular energy expenditure level no matter how active you get.”
This is still just a hypothesis. He and others will need to gather more evidence to validate it, and reconcile contradictory evidence showing that people can burn more energy as they add physical activity. So for now, it’s a fascinating possibility, among all the others, that may help explain why joining a gym as a sole strategy to lose weight is often an exercise in futility.
9) The government and the food industry are doling out unscientific advice
Since 1980, the obesity prevalence has doubled worldwide with about 13 percent of the global population now registering as obese, according to the World Health Organization. In the United States, nearly 70 percent of the population is either overweight or obese.
A lack of exercise and too many calories have been depicted as equal causes of the crisis. But as researchers put it in an article in BMJ, “You cannot outrun a bad diet.”
Since at least the 1950s, Americans have been told that we can. This Public Health Reports paper outlines the dozens of government departments and organizations — from the American Heart Association to the US Department of Agriculture — whose campaigns suggested more physical activity (alone or in addition to diet) to reverse weight gain.
Unfortunately, we are losing the obesity battle because we are eating more than ever. But the exercise myth is still regularly deployed by the food and beverage industry — which are increasingly under fire for selling us too many unhealthy products.
“Physical activity is vital to the health and well-being of consumers,” Coca-Cola says. The company has been aligning itself with exercise since the 1920s, and was recently exposed by the New York Times for funding obesity researchers who emphasize a lack of physical activity as the cause of the the epidemic.
It’s just one of many food companies that’s encouraging us to get more exercise (and keep buying their products while while we’re at it): PepsiCo, Cargill, and Mondelez have all emphasized physical activity as a cause of obesity.
The exercise myth for weight loss also still appears in high-profile initiatives like the first lady’s Let’s Move! campaign — largely because of the food industry’s lobbying efforts, according to Marion Nestle, New York University nutrition professor. The White House’s exercise focus to end childhood obesity, Nestle said, was “a strategic decision to make the message positive and doable and, at the same time, keep the food industry off its back.”
But this focus on calories-out, or the calories we can potentially burn in exercise, is “an inadequate and a potentially dangerous approach, because it is liable to encourage people to ignore or underestimate the greater impact of energy-in,” an obesity doctor and professor wrote in the journal Public Health Nutrition.
In other words, we can lose sight of the fact that it’s mostly too much food that’s making us fat.
“There are all kinds of reasons to exercise that are good for your health,” says Diana Thomas, a Montclair State University obesity researcher. “However, if you’re trying to lose weight, the biggest problem I see is food. We need to cut back the food we’re eating.”
The evidence is now clear: Exercise is excellent for health, but it’s not important for weight loss. The two things should never be given equal weight in the obesity debate.
10) So what actually works for weight loss?
At the individual level, some very good research on what works for weight loss comes from the National Weight Control Registry, a study that has parsed the traits, habits, and behaviors of adults who have lost at least 30 pounds and kept it off for a minimum of one year. They currently have more than 10,000 members enrolled in the study, and these folks respond to annual questionnaires about how they’ve managed to keep their weight down.
The researchers behind the study found that people who have had success losing weight share a few things in common: They weigh themselves at least once a week. They restrict their calorie intake, stay away from high-fat foods, and watch their portion sizes. They also exercise regularly.
But note: These folks use physical activity in addition to calorie counting and other behavioral changes. Every reliable expert I’ve ever spoken to on weight loss says the most important thing a person can do is to limit calories in a way they like and can sustain, and focus on eating healthfully.
In general, diet with exercise can work better than calorie cutting alone, but with only marginal additional weight-loss benefits. Consider this chart from a randomized trial that was done on a group of overweight folks: The group that restricted calories lost about the same amount of weight as the group that dieted and exercised, though the exercisers didn’t cut as many calories:
If you embark on a weight-loss journey that involves both adding exercise and cutting calories, Montclair’s Diana Thomas warned not to count those calories burned in physical activity toward extra eating.
“Pretend you didn’t exercise at all,” she said. “You will most likely compensate anyway so think of exercising just for health improvement but not for weight loss.”
You have been working out diligently for a few months, and have begun to get frustrated with the process. When you began, you could see gains on a consistent basis, and the gains motivated you to continue working out. You ran across inspiration in the gym by meeting people that had already achieved the body you want. You took the time to talk to those people, some of them trainers, and you took their advice regarding your workout regimen.
However, now it seems like you can no longer move the scale. One problem than some face is believing the myth that as long as you are regularly working out you can eat whatever you want. When you begin working out the hardest thing to get under control, for some, is the actual diet. What you eat directly affects the productivity of your workout.
“If you’re still eating lots of processed fats and refined sugars, cutting them out and replacing them with good fats like the omega threes found in fish and unrefined foods like fruits, vegetables and whole grains will make an enormous and noticeable difference in your physique very quickly. If your diet is low in protein, simply adding a complete protein food like chicken breast, fish or egg whites at each meal will muscle you up fast. No matter how hard you train or what type of training routine you’re on, it’s all in vain if you don’t provide yourself with the right nutritional support.”
This is not what we want to hear because some of us, honestly, hope that working out alone would be enough because we don’t want to part with some of our favorite foods. We cannot train the state of the body without taking into account what we put into the body. “Nutrition is important when exercising so that your body is able to endure your workout, recover from it, and get stronger.” You must remember just as you work out to get leaner and stronger, food also provides the necessary strength.
Many of us are not knowledgeable about good nutrition. We grew up eating what our parents knew from their parents, or what could be afforded. It’s wise to seek the professional help of a dietician or nutritionist to set you on a productive path regarding food. The goal is to be efficient in the kitchen, and the gym. it has even been argued by some that when one is new to working out the diet is actually more important that the gym.
– Christian Starr
Providing healthy food to children doesn’t just impact their health; it might give them a leg up in the classroom as well. Researchers analyzed the eating patterns and test scores of 4,245 Australian children (ages 8-15) to see if food choices relate to academics. They found that kids who ate vegetables every night at dinner scored signiﬁcantly higher in spelling and writing than kids who ate the fewest vegetables, and that eating breakfast daily and at least 2 servings of fruit daily were also linked with signiﬁcantly higher scores in writing. On the other hand, kids who drank the most sugary drinks (like soda) scored signiﬁcantly lower in reading, writing, grammar/punctuation, and numeracy than those who drank the fewest.
Appetite. 2017 May 6. pii: S0195-6663(17)30374-4. (Burrows T et al.)